The Path to Synthetic Biology

OpenAI's most capable general-purpose model, ideal for scientific writing and logical reasoning.

Google's multimodal large model, excelling in long-text processing and literature analysis.

Developer version of Gemini with free Pro model access and large context window.

Model launched by xAI with real-time Twitter feed integration.

AI-powered search engine with real-time web access, providing accurate literature citations.

DeepSeek, the shining star of Chinese open-source models with exceptional coding and mathematical capabilities.

Ad-free AI search engine with structured search results display.

ByteDance's AI assistant with excellent voice interaction, ideal for daily Q&A.

From Moonshot AI, supports ultra-long lossless context, excelling at reading long papers.

Alibaba's AI model with strong comprehensive capabilities, suitable for business and document analysis.

World's largest academic literature index database, essential for research.

NIH-maintained biomedical literature database, the most authoritative search platform in life sciences.

World's most authoritative academic citation database, essential for research evaluation and literature review.

AI-powered free academic search engine with accurate one-sentence summaries (TLDR) and citation intent analysis.

Comprehensive academic platform providing literature news, academic community, and research tools.

Microsoft Bing's academic search with clean interface and wide resource coverage.

Leading global academic database platform covering journal articles, dissertations (PQDT), and e-books across humanities, social sciences, biomedicine and more.

China's largest Chinese academic literature database, essential for finding theses and dissertations.

Comprehensive Chinese academic resource database covering journals, patents, and standards.

Aggregates massive Chinese and English literature, providing free plagiarism checking.

Chinese Academy of Sciences' public welfare platform, providing free access to 80 million full-text articles with iFlytek translation.

A public-interest, free, and open academic journal ranking and partition reference platform, covering 22,299 journals with search and subject browsing.

The ultimate PDF reader with AI Copilot for word translation, figure/formula explanation, and core conclusion summarization.

Excellent literature topology network visualization tool. Input one paper to instantly map the field's context.

Your AI postdoc assistant that automatically extracts experimental data, methods, and results from vast literature into tables.

Breaking academic barriers, free download of most paid papers worldwide.

Literature mutual aid platform solving difficult paper downloads through community power.

Chinese literature download platform with massive literature resource search and download.

Academic resource download navigation without VPN needed.

Academic navigation site aggregating multiple Google Scholar mirrors and download portals.

Provides literature download plus e-books and patent search.

World's most classic literature management tool, essential paper writing assistant for researchers.

Free open-source literature management tool with rich plugins, dramatically improving research efficiency.

Professional SCI literature reader with full-text translation, note management, and literature analysis.

AI-driven literature reading and management platform providing summary, translation, and analysis.

China's official patent search system with the most authoritative data.

Powerful patent search engine with user-friendly interface and full-text search.

Global patent search database provided by European Patent Office.

Chinese patent full-text free download tool.

US patent full-text free download tool.

European patent full-text free download tool.

Well-known NMR carbon spectrum database in China.

Natural product magnetic resonance database for structure elucidation.

Global Natural Products Social molecular networking, the ultimate mass spectrometry data analysis tool.

Top AI mass spectrometry tool integrating CSI:FingerID to directly predict metabolite structures from high-res MS/MS data.

NMR-based rapid natural product structure deduplication and identification tool.

Deep learning-assisted spectrum analysis tool.

Probabilistic prediction tool for NMR structure elucidation.

Links peptide mass spectrometry data to genomic biosynthetic gene clusters.

Comprehensive marine natural product database, authoritative platform for discovering novel marine scaffolds and highly active molecules.

Traditional Chinese Medicine systems pharmacology database containing massive TCM active ingredients and target information.

Classic species-metabolite relationship database for precise queries of natural products in specific plants or microorganisms.

Encyclopedia focused on natural products and their biological activities.

Microbial natural product atlas providing structure and source information.

Antimicrobial peptide structure and activity database.

World's largest chemical molecule database provided by NIH.

Free chemical structure database provided by Royal Society of Chemistry.

Mass Spectrometry library, one of the largest free untargeted metabolomics and natural product MS databases.

Database of chemical entities of biological interest.

Authoritative chemistry research platform by CAS, covering 275M+ substances, 150M+ reactions, and 59M+ references.

Extremely intuitive drug-likeness, water solubility, brain penetration, and ADME prediction tool, preferred for research.

Predicts unknown target proteins of small molecule natural products in humans based on reverse pharmacophore matching.

Comprehensive evaluation of drug absorption, distribution, metabolism, excretion, and toxicity.

Chemical calculator for rapid molecular formula and isotope distribution calculation.

AI-based comprehensive biological analysis platform.

Collection of bioinformatics online tools provided by EBI.

National Center for Biotechnology Information, core gateway for life sciences.

China's National Genomics Data Center providing massive genomic data resources.

Extremely powerful eukaryotic genome browser and annotation database, preferred for transcript lookup.

Powerful batch processing and analysis tool for biological sequences.

Gene tissue expression database for studying gene expression patterns across different tissues.

Comprehensive human gene database integrating gene function, expression, variation and more.

Integrated medicinal plant omics platform with 1,007 high-quality plant genomes, 800M+ genes, and 2,158 transcriptomic samples.

Saccharomyces cerevisiae genome database providing detailed yeast gene sequence, annotation, function, and protein information.

Tobacco genome database developed by Huazhong Agricultural University providing tobacco genome and transcriptomics data.

US Department of Energy Joint Genome Institute providing microbial genome databases like IMG, GOLD, Genome Portal and BBTools.

Fast gene functional annotation tool based on eggNOG database supporting GO, KEGG, COG annotations, 2-15x faster than BLAST.

Database of protein families, domains, and functional sites.

Sequence homology search tool based on hidden Markov models.

NCBI conserved domain database search.

Protein structure classification database.

Fast and accurate multiple sequence alignment tool.

High-performance multiple sequence alignment program.

Software for editing, visualizing, and analyzing multiple sequence alignments.

Molecular evolutionary genetics analysis software, essential for phylogenetic tree construction.

Online phylogenetic tree visualization and annotation tool.

Circular visualization software for data and information, commonly used for genome mapping.

Oligonucleotide properties calculator.

Professional primer analysis tool from IDT for analyzing dimers and hairpin structures.

Eukaryotic gene and intron annotation prediction tool.

Harvard-developed easy-to-use CRISPR/Cas (Cas9, Cpf1, etc.) sgRNA design and off-target prediction tool.

One of the most cited 'gold standard' tools, evaluating off-target effects and outputting primer sequences for cloning.

Most popular comprehensive plasmid and sequence design platform in industry with powerful CRISPR gRNA design module.

Ultra-fast search for CRISPR/Cas off-target sites with customizable mismatches and bulges.

Free online design tool from leading CRISPR company, especially good for multi-gene knockout experiments.

World's largest non-profit plasmid repository, essential for finding validated plasmid maps, sequences, and backbones.

NEB's official seamless cloning (Gibson Assembly/HiFi) primer design tool.

Synthetic biology core tool from Salis Lab for precise prediction and design of ribosome binding sites (RBS) to control translation rates.

Classic bacterial promoter prediction tool for finding transcription start sites and -10/-35 regions.

Standard tool for predicting RNA secondary structure, essential for riboswitch design or mRNA stability optimization.

AI-based protein structure and function analysis platform.

Peptide and protein online tools from Novopro.

Proteomics server provided by Swiss Institute of Bioinformatics.

Bioinformatics toolkit from Technical University of Denmark.

Efficient protein sequence clustering tool.

Google DeepMind's latest generation protein structure prediction model.

Run AlphaFold2 in browser without local computing power.

Cutting-edge molecular structure prediction model with top accuracy.

Fully automated protein homology modeling server.

Protein structure prediction tool from Baker Lab.

Meta's language model-based fast protein structure prediction.

Professional protein analysis and structure prediction server.

Iterative thread assembly algorithm, classic structure prediction tool.

Ab initio protein structure prediction tool.

Baker Lab's protein structure prediction server.

Atomic movability-based protein structure prediction tool.

Protein secondary structure prediction and classification.

Web server for protein structure alignment.

Network platform integrating multiple structure prediction services.

Standard software in molecular simulation and docking.

Faster and more accurate open-source docking engine.

Hybrid algorithm protein-protein/docking server.

Diffusion model-based molecular docking tool.

Protein-protein docking server from Boston University.

Peptide-protein docking tool from University of Warsaw.

Peptide-protein docking server from HUST.

Flexible peptide docking server from Meiler Lab.

Biomolecular simulation portal from Paris Diderot.

Protein cavity detection tool from Peking University.

Compound SAR analysis and docking tool.

Deep learning-based virtual screening tool.

Universal protein resource with sequence and function info.

Protein sequence database from NCBI.

Database of protein structures predicted by AlphaFold.

Protein Data Bank with experimental structures.

World's largest PPI network database.

Molecular interaction database from EBI.

Human protein atlas with expression data.

Membrane protein orientation database.

Codon optimization for heterologous expression.

Predicts protein solubility.

Predicts signal peptides and cleavage sites.

Deep learning transmembrane prediction.

Analyzes rare codons.

Phosphorylation site prediction.

SUMOylation site prediction.

Multi-scale target prediction.

Enzyme similarity for SSN construction.

Fast structure search like BLAST.

Contrastive learning enzyme annotation.

Deep learning enzyme mining.

ML protease prediction.

Diffusion model protein generation from Baker Lab.

Deep learning affinity optimization.

DL protein-ligand binding design.

AI protein optimization.

ML binding affinity prediction.

Enzyme specificity optimization.

Protease stability prediction.

ProteinMPNN with ligand support.

DL sequence design from structure.

Mutation stability effect.

Structure-aware protein LM from Westlake.

Classic protein visualization software.

Next-gen molecular visualization.

Smooth web 3D visualization.

Lightweight WebGL visualization.

Alignment figure tool.

Sequence LOGO tool.

Chimera color documentation.

Most authoritative secondary metabolite BGC mining and analysis tool.

Deep learning BGC mining tool for discovering novel 'dark matter' gene clusters.

Calculates gene cluster similarity and builds GCF networks.

Antibiotic resistance target search for new antibiotic discovery.

Secondary metabolite biosynthesis mining platform.

Fungal secondary metabolite BGC mining tool.

Fungal antibiotic resistance target search.

Fungal BGC functional analysis tool.

Secondary metabolite biosynthesis gene finder.

Tool for mining bacteriocins and RiPPs.

RiPP automatic mining and analysis.

Plant BGC analysis platform.

Classic PKS and NRPS domain analysis.

Phylogeny-based secondary metabolite domain detection.

Predicts NRPS adenylation domain substrate specificity.

PKS structure and sequence analysis.

Fungal BGC analysis and visualization.

Lasso peptide domain prediction.

PKS/NRPS adenylation domain substrate prediction.

Deep learning NRPS adenylation domain prediction.

NRPS/PKS analysis and product prediction.

Kyoto Encyclopedia of Genes and Genomes, authoritative pathway analysis database.

Powerful biocatalysis and computer-aided retrosynthesis platform.

Curated metabolic pathway database with detailed species-specific models.

Automated enzyme matching and screening for metabolic pathways.

Standard BGC database with known functions.

antiSMASH predicted BGC database.

PKS/NRPS BGC database from Japanese NITE.

BGC atlas from JGI.

Largest genome-scale metabolic model database.

Natural products discovery center database.

Most authoritative drug target and interaction database.

Bioactive molecule database from EBI.

Protein-ligand binding affinity database.

IUPHAR drug target and receptor database.

Clinical pharmacogenomics database.

Cancer Genome Atlas with multi-omics data for 33 cancers.

Cancer genomics visualization and analysis.

Cancer gene expression analysis from Peking University.

Cell signaling network database.

Chemical information search platform.

Comprehensive chemical supplier.

Domestic chemical platform.

Sinopharm reagents.

Domestic bio reagent brand.

Leading global reagent supplier.

World's largest scientific provider.

Leading bio reagent supplier.

Domestic bio reagent platform.

China's largest microbial strain center.

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